HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis

Castelli, M; Piobbico, D; Chiacchiaretta, M; Brunacci, C; Pieroni, S; Bartoli, D; Gargaro, M; Fallarino, F; Puccetti, P; Soddu, S; Della-Fazia, MA; Servillo, G

Della-Fazia, MA; Servillo, G (reprint author), Univ Perugia, Dept Expt Med, Perugia, Italy.; Servillo, G (reprint author), Univ Perugia, Ctr Univ Ric Genom Funz CURGeF, Perugia, Italy.

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Abstract

Apoptotic signalling by p53 occurs at both transcriptional and non-transcriptional levels, as p53 may act as a direct apoptogenic stimulus via activat......

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