Mice with dysfunctional TGF-beta signaling develop altered intestinal microbiome and colorectal cancer resistant to 5FU

Wang, ZAH; Hopson, LM; Singleton, SS; Yang, XC; Jogunoori, W; Mazumder, R; Obias, V; Lin, P; Nguyen, BN; Yao, M; Miller, L; White, J; Rao, SY; Mishra, L

Rao, SY; Mishra, L (corresponding author), Northwell Hlth, Inst Bioelect Med, Feinstein Inst Med Res, 350 Community Dr, Manhasset, NY 11030 USA.; Mishra, L (corresponding author), Northwell Hlth, Div Gastroenterol, Cold Spring Harbor Lab, 350 Community Dr, Manhasset, NY 11030 USA.; Rao, SY; Mishra, L (corresponding author), Northwell Hlth, Div Hepatol, Cold Spring Harbor Lab, 350 Community Dr, Manhasset, NY 11030 USA.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2021; 1867 (10):

Abstract

Emerging data show a rise in colorectal cancer (CRC) incidence in young men and women that is often chemoresistant. One potential risk factor is an al......

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