Generation of a Novel HLA Class I Transgenic Mouse Model Carrying a Knock-in Mutation at the beta(2)-Microglobulin Locus

Harada, N; Fukaya, S; Wada, H; Goto, R; Osada, T; Gomori, A; Ikizawa, K; Sakuragi, M; Oda, N

Harada, N (reprint author), Taiho Pharmaceut Co Ltd, Discovery & Preclin Res Div, 3 Okubo, Tsukuba, Ibaraki 3002611, Japan.

JOURNAL OF IMMUNOLOGY, 2017; 198 (1): 516

Abstract

We generated a series of monochain HLA class I knock-in (KI) mouse strains, in which a chimeric HLA class I molecule (alpha 1/alpha 2 domain of HLA-A*......

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