Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

Krueger, J; Santinon, F; Kazanova, A; Issa, ME; Larrivee, B; Kremer, R; Milhalcioiu, C; Rudd, CE

Rudd, CE (corresponding author), Rosemont Hosp CR HMR Montreal, Div Immunooncol, Res Ctr Maisonneuve, Montreal, PQ, Canada.; Rudd, CE (corresponding author), Univ Montreal, Dept Microbiol Infect & Immunol, Montreal, PQ, Canada.; Rudd, CE (corresponding author), McGill Univ, Dept Med, Div Expt Med, Hlth Ctr, Montreal, PQ, Canada.

PLOS ONE, 2021; 16 (6):

Abstract

Immunotherapy using checkpoint blockade (ICB) with antibodies such as anti-PD-1 has revolutionised the treatment of many cancers. Despite its use to t......

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