Mutation-induced DNMT1 cleavage drives neurodegenerative disease

Wang, WC; Zhao, XS; Shao, YJ; Duan, XY; Wang, YL; Li, JL; Li, JW; Li, DL; Li, XK; Wong, JM

Wong, JM (corresponding author), East China Normal Univ, Shanghai Key Lab Regulatory Biol, Fengxian Dist Cent Hosp ECNU Joint Ctr Translat M, Inst Biomed Sci, Shanghai 200241, Peoples R China.; Wong, JM (corresponding author), East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China.; Wong, JM (corresponding author), Fengxian Dist Cent Hosp, Joint Ctr Translat Med, 6600th Nanfeng Rd, Shanghai 201499, Peoples R China.; Li, XK (corresponding author), Zhejiang Univ, Childrens Hosp, Sc

SCIENCE ADVANCES, 2021; 7 (36):

Abstract

Specific mutations within the replication foci targeting sequence (RFTS) domain of human DNMT1 are causative of two types of adult-onset neurodegenera......

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