Activation of the Intracellular Pattern Recognition Receptor NOD2 Promotes Acute Myeloid Leukemia (AML) Cell Apoptosis and Provides a Survival Advantage in an Animal Model of AML

Buteyn, NJ; Santhanam, R; Merchand-Reyes, G; Murugesan, RA; Dettorre, GM; Byrd, JC; Sarkar, A; Vasu, S; Mundy-Bosse, BL; Butchar, JP; Tridandapani, S

Butchar, JP (corresponding author), Ohio State Univ, 385P Wiseman Hall,400 W 12th Ave, Columbus, OH 43210 USA.; Tridandapani, S (corresponding author), Ohio State Univ, 385C Wiseman Hall,400 W 12th Ave, Columbus, OH 43210 USA.

JOURNAL OF IMMUNOLOGY, 2020; 204 (7): 1988

Abstract

TLRs, a family of membrane-bound pattern recognition receptors found on innate immune cells, have been well studied in the context of cancer therapy. ......

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