Pterostilbene Increases LDL Metabolism in HL-1 Cardiomyocytes by Modulating the PCSK9/HNF1 alpha/SREBP2/LDLR Signaling Cascade, Upregulating Epigenetic hsa-miR-335 and hsa-miR-6825, and LDL Receptor Expression

Lin, YK; Yeh, CT; Kuo, KT; Yadav, VK; Fong, IH; Kounis, NG; Hu, P; Hung, MY

Hung, MY (corresponding author), Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med,Div Cardiol, Taipei 110, Taiwan.; Hung, MY (corresponding author), Taipei Med Univ, Taipei Heart Inst, Taipei 110, Taiwan.; Hung, MY (corresponding author), Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Cardiol, New Taipei 23561, Taiwan.

ANTIOXIDANTS, 2021; 10 (8):

Abstract

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can promote the degradation of low-density lipoprotein (LDL) receptor (LDLR), leading to hyperch......

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