CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells

Kumar, S; Zeng, ZX; Bagati, A; Tay, RE; Sanz, LA; Hartono, SR; Ito, Y; Abderazzaq, F; Hatchi, E; Jiang, P; Cartwright, ANR; Olawoyin, O; Mathewson, ND; Pyrdol, JW; Li, MZ; Doench, JG; Booker, MA; Tolstorukov, MY; Elledge, SJ; Chedin, F; Liu, XS; Wucherpfennig, KW

Wucherpfennig, KW (corresponding author), Dana Farber Canc Inst, Dept Canc Immunol & Virol, Smith Bldg,Room 736,450 Brookline Ave, Boston, MA 02115 USA.; Liu, XS (corresponding author), Harvard TH Chan Sch Publ Hlth, Dana Farber Canc Inst, Dept Data Sci, Boston, MA 02215 USA.

CANCER DISCOVERY, 2021; 11 (8): 2050

Abstract

A number of cancer drugs activate innate immune pathways in tumor cells but unfortunately also compromise antitumor immune function. We discovered tha......

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