Upregulation of neuronal PGC-1 alpha ameliorates cognitive impairment induced by chronic cerebral hypoperfusion

Han, B; Jiang, W; Liu, HJ; Wang, JJ; Zheng, K; Cui, P; Feng, Y; Dang, C; Bu, YL; Wang, QM; Ju, ZY; Hao, JW

Hao, JW (corresponding author), Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China.; Hao, JW (corresponding author), Tianjin Med Univ, Dept Neurol, Gen Hosp, Tianjin 300052, Peoples R China.; Ju, ZY (corresponding author), Jinan Univ, Inst Aging & Regenerat Med, Key Lab Regenerat Med, Minist Educ, Guangzhou 510632, Peoples R China.

THERANOSTICS, 2020; 10 (6): 2832

Abstract

Rationale: Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD), but the specific molecular mechanism regulating these even......

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