Small-Molecule Antiviral beta-D-N-4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Agostini, ML; Pruijssers, AJ; Chappell, JD; Gribble, J; Lu, XT; Andres, EL; Bluemling, GR; Lockwood, MA; Sheahan, TP; Sims, AC; Natchus, MG; Saindane, M; Kolykhalov, AA; Painter, GR; Baric, RS; Denison, MR

Denison, MR (reprint author), Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37212 USA.; Denison, MR (reprint author), Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA.

JOURNAL OF VIROLOGY, 2019; 93 (24):

Abstract

Coronaviruses (CoVs) have emerged from animal reservoirs to cause severe and lethal disease in humans, but there are currently no FDA-approved antivir......

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