Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial

Mellinghoff, IK; Lu, M; Wen, PY; Taylor, JW; Maher, EA; Arrillaga-Romany, I; Peters, KB; Ellingson, BM; Rosenblum, MK; Chun, S; Le, K; Tassinari, A; Choe, S; Toubouti, Y; Schoenfeld, S; Pandya, SS; Hassan, I; Steelman, L; Clarke, JL; Cloughesy, TF

Mellinghoff, IK (通讯作者)，Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA.

NATURE MEDICINE, 2023; 29 (3): 615

Abstract

The dual IDH1/IDH2 inhibitor vorasidenib exhibited better brain permeability and target engagement than ivosidenib in a pilot perioperative randomized......

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