Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder

Jiang, WJ; Jia, N; Guo, CW; Wen, J; Wu, LQ; Ogi, T; Zhang, HW

Zhang, HW (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Shanghai Inst Pediat Res, Dept Pediat Endocrinol & Genet,Sch Med, Shanghai, Peoples R China.; Ogi, T (corresponding author), Nagoya Univ, Res Inst Environm Med RIeM, Dept Genet, Nagoya, Aichi, Japan.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2021; 1867 (6):

Abstract

TOP3A promotes processing of double Holliday junction dissolution and also plays an important role in decatenation and segregation of human mtDNA. Rec......

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