SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3K delta) inhibitors

Wei, MM; Zhang, X; Wang, X; Song, ZL; Ding, J; Meng, LH; Zhang, A

Zhang, A (reprint author), Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Synthet Organ & Med Chem Lab, Shanghai 201203, Peoples R China.; Meng, LH (reprint author), Chinese Acad Sci, SIMM, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 2012

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017; 125 ( ): 1156

Abstract

PI3K delta is a key component in the aberrant signaling transduction in B cell malignancy, therefore specific targeting PI3K delta has become an attra......

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