C-Terminal Cysteine PEGylation of Adalimumab Fab with an Engineered Interchain SS Bond

Nakamura, H; Anraku, M; Oda-Ueda, N; Ueda, T; Ohkuri, T

Ohkuri, T (corresponding author), Sojo Univ, Fac Pharmaceut Sci, Nishi Ku, 4-22-1 Ikeda, Kumamoto 8600082, Japan.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2020; 43 (3): 418

Abstract

Conjugation with polyethylene glycol (PEG) is performed to increase serum half-life of the Fab for clinical applications. However, current designs for......

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