Identification of a novel SPT inhibitor WXP-003 by docking-based virtual screening and investigation of its anti-fungi effect

Wang, X; Yang, X; Sun, X; Qian, Y; Fan, MY; Zhang, ZH; Deng, KY; Lou, ZX; Pei, ZJ; Zhu, JY

Pei, ZJ (corresponding author), Nanjing Med Univ, Affiliated Wuxi Peoples Hosp 2, 68 Zhongshan Rd, Wuxi 214002, Jiangsu, Peoples R China.; Zhu, JY (corresponding author), Jiangnan Univ, Sch Pharmaceut Sci, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021; 36 (1): 1007

Abstract

Serine palmitoyltransferase (SPT) plays the key role on catalysing the formation of 3-ketodihydrosphingosine, which is the first step of the de novo b......

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