Development of MBRI-001, a deuterium-substituted plinabulin derivative as a potent anti-cancer agent

Ding, ZP; Cheng, HJ; Wang, SX; Hou, YW; Zhao, JC; Guan, HS; Li, WB

Li, WB (reprint author), Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (6): 1416

Abstract

Plinabulin, a drug targeting microtubule of cancer cells, has been currently tried in its phase III clinical study. However, low efficacy caused by po......

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