pH-dependent conformational dynamics of beta-secretase 1: A molecular dynamics study

Mermelstein, DJ; McCammon, JA; Walker, RC

Mermelstein, DJ (reprint author), Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA.

JOURNAL OF MOLECULAR RECOGNITION, 2019; 32 (3):

Abstract

Beta-secretase 1 (BACE-1) is an aspartyl protease implicated in the overproduction of beta-amyloid fibrils responsible for Alzheimer disease. The proc......

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