Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs

Shah, RR; Redmond, JM; Mihut, A; Menon, M; Evans, JP; Murphy, JA; Bartholomew, MA; Coe, DM

Shah, RR (corresponding author), GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England.; Shah, RR (corresponding author), Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, 295 Cathedral St, Glasgow G1 1XL, Lanark, Scotland.

BIOORGANIC & MEDICINAL CHEMISTRY, 2020; 28 (5):

Abstract

PROTACs have recently emerged as a novel paradigm in drug discovery. They can hijack existing biological machinery to selectively degrade proteins of ......

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