A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

Fitzgerald, K; White, S; Borodovsky, A; Bettencourt, BR; Strahs, A; Clausen, V; Wijngaard, P; Horton, JD; Taubel, J; Brooks, A; Fernando, C; Kauffman, RS; Kallend, D; Vaishnaw, A; Simon, A

Fitzgerald, K (reprint author), Alnylam Pharmaceut, 300 Third St, Cambridge, MA 02142 USA.

NEW ENGLAND JOURNAL OF MEDICINE, 2017; 376 (1): 41

Abstract

BACKGROUND Inclisiran (ALN-PCSsc) is a long-acting RNA interference (RNAi) therapeutic agent that inhibits the synthesis of proprotein convertase subt......

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