Structural investigation of tetrahydropteridin analogues as selective PLK1 inhibitors for treating cancer through combined QSAR techniques, molecular docking, and molecular dynamics simulations-MedSci.cn

Structural investigation of tetrahydropteridin analogues as selective PLK1 inhibitors for treating cancer through combined QSAR techniques, molecular docking, and molecular dynamics simulations

Tong, JB; Luo, D; Bian, S; Zhang, X

Tong, JB (corresponding author), Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Xian 710021, Peoples R China.; Tong, JB (corresponding author), Shaanxi Key Lab Chem Addit Ind, Xian 710021, Peoples R China.

JOURNAL OF MOLECULAR LIQUIDS, 2021; 335 ():

Abstract

The forced expression of Polo-like kinase 1 (PLK1) was found to be carcinogenic, making PLK1 an attractive drug target for the treatment of tumor dise......

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