Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

Antonucci, L; Di Magno, L; D'Amico, D; Manni, S; Serrao, SM; Di Pastena, F; Bordone, R; Yurtsever, ZN; Caimano, M; Petroni, M; Giorgi, A; Schinina, ME; Yates, JR; Di Marcotullio, L; De Smaele, E; Checquolo, S; Capalbo, C; Agostinelli, E; Maroder, M;

Coni, S; Canettieri, G (reprint author), Sapienza Univ Rome, Dept Mol Med, Viale Regina Elena 291, I-00161 Rome, Italy.

INTERNATIONAL JOURNAL OF ONCOLOGY, 2019; 54 (2): 505

Abstract

The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The ......

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