Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS(G12C)

Mortier, J; Friberg, A; Badock, V; Moosmayer, D; Schroeder, J; Steigemann, P; Siegel, F; Gradl, S; Bauser, M; Hillig, RC; Briem, H; Eis, K; Bader, B; Nguyen, D; Christ, CD

Mortier, J; Nguyen, D; Christ, CD (corresponding author), Bayer AG, Res & Dev, Pharmaceut, Mullerstr 178, D-13342 Berlin, Germany.

CHEMMEDCHEM, 2020; 15 (10): 827

Abstract

Due to its frequent mutations in multiple lethal cancers, KRAS is one of the most-studied anticancer targets nowadays. Since the discovery of the drug......

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