Perfluoro-tert-butyl Group-Derived Capmatinib: Synthesis, Biological Evaluation and Its Application in 19F Magnetic Resonance Imaging

Zhang, XN; Wang, LT; Huang, RM; Wang, JB; Yan, QF

Yan, QF (通讯作者)，East China Univ Sci & Technol, Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat & Feringa Nobel, 130 Meilong Rd, Shanghai 200237, Peoples R China.;Huang, RM (通讯作者)，Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China.;Wang, JB (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, 639 Zhizaoju Rd, Shanghai 200025, Peoples R China.

CHEMBIOCHEM, 2023; 24 (19):

Abstract

Capmatinib is an FDA-approved drug to treat metastatic non-small cell lung cancer with MET-exon 14 skipping. Herein, the perfluoro-tert-butyl group, w......

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