CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4(+) T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4(+) T cell enrichment in humanized mice

Xiao, QQ; Chen, SL; Wang, QK; Liu, ZP; Liu, S; Deng, H; Hou, W; Wu, DC; Xiong, Y; Li, JF; Guo, DY

Guo, DY (reprint author), Sun Yat Sen Univ, Sch Med, Lab Med Virol, Zhongshan Erlu 74, Guangzhou 510080, Guangdong, Peoples R China.; Chen, SL (reprint author), Wuhan Univ, Sch Basic Med Sci, Inst Med Virol, Wuhan 430071, Hubei, Peoples R China.

RETROVIROLOGY, 2019; 16 ():

Abstract

BackgroundThe chemokine receptor CCR5, which belongs to the superfamily of G protein-coupled receptors, is the major co-receptor for HIV-1 entry. Indi......

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