Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription

Kim, ET; Dybas, JM; Kulej, K; Reyes, ED; Price, AM; Akhtar, LN; Orr, A; Garcia, BA; Boutell, C; Weitzman, MD

Weitzman, MD (corresponding author), Childrens Hosp Philadelphia, Div Protect Immun, Philadelphia, PA USA.; Weitzman, MD (corresponding author), Childrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA USA.; Weitzman, MD (corresponding author), Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.; Weitzman, MD (corresponding author), Univ Penn, Epigenet Program, Perelman Sch Med, Philadelphia, PA 19104 USA.

NATURE MICROBIOLOGY, 2021; 6 (2): 234

Abstract

Intrinsic antiviral host factors confer cellular defence by limiting virus replication and are often counteracted by viral countermeasures. We reasone......

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