Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose

Yin, DD; Xia, XY; Zhang, JL; Zhang, SY; Liao, F; Zhang, G; Zhang, Y; Hou, QQ; Yang, X; Wang, H; Ma, ZG; Wang, HY; Zhu, YP; Zhang, W; Wang, YL; Liu, B; Wang, LL; Xu, H; Shu, Y

Xu, H; Shu, Y (reprint author), Sichuan Univ, Dept Lab Med, Natl Key Lab Biotherapy,West China Hosp, Key Lab Sichuan Prov,Collaborat Innovat Ctr Bioth, Chengdu, Sichuan, Peoples R China.; Wang, LL; Xu, H (reprint author), Sichuan Univ, Dept Lab Med, Res C

ONCOTARGET, 2017; 8 (8): 13575

Abstract

Thiopurines are widely used as anticancer and immunosuppressive agents. However, life-threatening myelotoxicity has been noticed and largely explained......

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