The loss of heterochromatin is associated with multiscale three-dimensional genome reorganization and aberrant transcription during cellular senescence

Zhang, XL; Liu, XH; Du, ZH; Wei, L; Fang, H; Dong, QY; Niu, J; Li, YD; Gao, JT; Zhang, MQ; Xie, W; Wang, XW

Wang, XW (corresponding author), Tsinghua Univ, MOE Key Lab Bioinformat, Ctr Synthet & Syst Biol, Dept Automat, Beijing 100084, Peoples R China.; Wang, XW (corresponding author), Beijing Natl Res Ctr Informat Sci & Technol, Bioinformat Div, Beijing 100084, Peoples R China.; Xie, W (corresponding author), Tsinghua Univ, Ctr Stem Cell Biol & Regenerat Med, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China.; Xie, W (corresponding author), THU PKU Ctr Life Sci, Beijing 100084, Peoples R China

GENOME RESEARCH, 2021; 31 (7): 1121

Abstract

Heterochromatin remodeling is critical for various cell processes. In particular, the "loss of heterochromatin" phenotype in cellular senescence is as......

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