MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition

Silvis, MR; Silva, D; Rohweder, R; Schuman, S; Gudipaty, S; Truong, A; Yap, J; Affolter, K; McMahon, M; Kinsey, C

McMahon, M; Kinsey, C (通讯作者)，Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA.;McMahon, M (通讯作者)，Univ Utah, Dept Oncol Sci, Salt Lake City, UT 84112 USA.;McMahon, M (通讯作者)，Univ Utah, Dept Dermatol, Salt Lake City, UT 84112 USA.;Kinsey, C (通讯作者)，Univ Utah, Dept Internal Med, Div Oncol, Salt Lake City, UT 84112 USA.

JOURNAL OF EXPERIMENTAL MEDICINE, 2023; 220 (3):

Abstract

Pharmacological inhibition of KRAS>RAF>MEK1/2>ERK1/2 signaling has provided no clinical benefit to patients with pancreatic ductal adenocarci......

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