An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL-rearranged acute lymphoblastic leukemia xenografts

Schewe, DM; Alsadeq, A; Sattler, C; Lenk, L; Vogiatzi, F; Cario, G; Vieth, S; Valerius, T; Rosskopf, S; Meyersieck, F; Alten, J; Schrappe, M; Gramatzki, M; Peipp, M; Kellner, C

Schewe, DM (reprint author), Univ Hosp Schleswig Holstein, Campus Kiel, Kiel, Germany.; Schewe, DM (reprint author), Univ Kiel, ALL BFM Study Grp, Pediat Hematol Oncol, Kiel, Germany.

BLOOD, 2017; 130 (13): 1543

Abstract

Antibody therapy constitutes a major advance in the treatment of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). To evaluate the efficacy and......

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