Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing gamma-secretase-independent ERK/CREB signaling

Chong, CM; Ke, MJ; Tan, Y; Huang, ZJ; Zhang, K; Ai, NN; Ge, W; Qin, DJ; Lu, JH; Su, HX

Lu, JH; Su, HX (reprint author), Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.; Qin, DJ (reprint author), Chinese Acad Sci, Guangdong Prov Key Lab Stem Cell & Regenerat Med, South China Inst Stem Cell Biol &

CELL DEATH & DISEASE, 2018; 9 ():

Abstract

Autophagy impairment is commonly implicated in the pathological characteristic of Alzheimer's disease (AD). Presenilin 1 (PS1) expression in human bra......

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