Tryptophan potentiates CD8(+) T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

Qin, R; Zhao, C; Wang, CJ; Xu, W; Zhao, JY; Lin, Y; Yuan, YY; Lin, PC; Li, Y; Zhao, SM; Huang, Y

Li, Y; Huang, Y (corresponding author), Fudan Univ, State Key Lab Genet Engn, Sch Life Sci, Shanghai, Peoples R China.; Li, Y; Huang, Y (corresponding author), Fudan Univ, Obstet & Gynecol Hosp, Shanghai, Peoples R China.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (7):

Abstract

Background Tryptophan catabolites suppress immunity. Therefore, blocking tryptophan catabolism with indoleamine 2,3-dioxygenase (IDO) inhibitors is pu......

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