Timed Ang2-Targeted Therapy Identifies the Angiopoietin-Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis

Gengenbacher, N; Singhal, M; Mogler, C; Hai, L; Milde, L; Pari, AAA; Besemfelder, E; Fricke, C; Baumann, D; Gehrs, S; Utikal, J; Felcht, M; Hu, JH; Schlesner, M; Offringa, R; Chintharlapalli, SR; Augustin, HG

Augustin, HG (corresponding author), Heidelberg Univ, European Ctr Angiosci ECAS, Med Fac Mannheim, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.; Augustin, HG (corresponding author), German Canc Res Ctr, DKFZ ZMBH Alliance, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

CANCER DISCOVERY, 2021; 11 (2): 424

Abstract

Recent clinical and preclinical advances have highlighted the existence of a previously hypothesized lymphogenous route of metastasis. However, due to......

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