Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks

Rubin, AJ; Parker, KR; Satpathy, AT; Qi, YY; Wu, BJ; Ong, AJ; Mumbach, MR; Ji, AL; Kim, DS; Cho, SW; Zarnegar, BJ; Greenleaf, WJ; Chang, HY; Khavari, PA

Chang, HY; Khavari, PA (reprint author), Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA.; Chang, HY (reprint author), Stanford Univ, Sch Med, Ctr Personal Dynam Regulomes, Stanford, CA 94305 USA.; Chang, HY (reprint author), Stanf

CELL, 2019; 176 (1-2): 361

Abstract

Here, we present Perturb-ATAC, a method that combines multiplexed CRISPR interference or knockout with genome-wide chromatin accessibility profiling i......

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