Cytotoxic synergy between alisertib and carboplatin versus alisertib and irinotecan are inversely dependent on MGMT levels in glioblastoma cells

Sak, M; Zumbar, CT; King, PD; Li, XH; Mifsud, CS; Usubalieva, A; Anderson, CD; Chesnick, HM; McElroy, JP; Chakravarti, A; Burton, EC; Lehman, NL

Lehman, NL (reprint author), Univ Louisville, Dept Pathol & Lab Med, Louisville, KY 40202 USA.; Lehman, NL (reprint author), Univ Louisville, Dept Biochem & Mol Genet, Louisville, KY 40202 USA.; Lehman, NL (reprint author), Univ Louisville, Brown Canc Ctr

JOURNAL OF NEURO-ONCOLOGY, 2019; 143 (2): 231

Abstract

IntroductionGlioblastoma remains difficult to treat and patients whose tumors express high levels of O-6-methylguanine DNA methyltransferase (MGMT) us......

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