Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2-Hippo signaling pathway

Zhang, Y; He, LJ; Huang, LL; Yao, S; Lin, N; Li, P; Xu, HW; Wu, XW; Xu, JL; Lu, Y; Li, YJ; Zhu, SL

Zhu, SL (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol & Hepatol, 58 Zhongshan 2nd Rd, Guangzhou 510630, Peoples R China.

CLINICAL AND TRANSLATIONAL MEDICINE, 2021; 11 (8):

Abstract

Intrinsic resistance to CDK4/6 inhibitors hinders their clinical utility in cancer treatment. Furthermore, the predictive markers of CDK4/6 inhibitors......

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