The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response

Zhang, Z; Luo, S; Barbosa, GO; Bai, MR; Kornberg, TB; Ma, DK

Zhang, Z (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Jinan, Peoples R China.; Zhang, Z; Ma, DK (corresponding author), Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA.; Ma, DK (corresponding author), Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA.; Ma, DK (corresponding author), Innovat Genom Inst, Berkeley, CA 94720 USA.

PLOS GENETICS, 2021; 17 (2):

Abstract

Dysregulation of collagen production and secretion contributes to aging and tissue fibrosis of major organs. How procollagen proteins in the endoplasm......

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