Microcystin-LR Induces NLRP3 Inflammasome Activation via FOXO1 Phosphorylation, Resulting in Interleukin-1 beta Secretion and Pyroptosis in Hepatocytes

Zhang, YL; Zhu, PP; Wu, XF; Yuan, TL; Su, ZY; Chen, SY; Zhou, YJ; Tao, WGA

Zhang, YL (corresponding author), Nantong Univ, Sch Med, Dept Biochem & Mol Biol, Qixiu Rd 19, Nantong 226001, Jiangsu, Peoples R China.

TOXICOLOGICAL SCIENCES, 2021; 179 (1): 53

Abstract

Microcystin-LR (MC-LR), the most common and toxic microcystin (MC) present in freshwater, poses a substantial threat to human health, especially hepat......

Full Text Link