Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability

Hettiaratchi, MH; O'Meara, MJ; O'Meara, TR; Pickering, AJ; Letko-Khait, N; Shoichet, MS

Shoichet, MS (corresponding author), Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada.; Shoichet, MS (corresponding author), Univ Toronto, Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada.; Shoichet, MS (corresponding author), Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada.

SCIENCE ADVANCES, 2020; 6 (34):

Abstract

Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC (ChABC) has shown promise in central nervous system (CNS) r......

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