Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity

Hamzic, S; Scharer, D; Offer, SM; Meulendijks, D; Nakas, C; Diasio, RB; Fontana, S; Wehrli, M; Schurch, S; Amstutz, U; Largiader, CR

Largiader, CR (corresponding author), Univ Bern, Bern Univ Hosp, Inst Clin Chem, Inselspital,INO F, CH-3010 Bern, Switzerland.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ():

Abstract

Aims The aim of this study was to identify risk variants and haplotypes that impair dihydropyrimidine dehydrogenase (DPD) activity and are, therefore,......

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