Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition

Wang, SJ; Zhao, ZJ; Feng, XY; Cheng, Z; Xiong, ZY; Wang, TT; Lin, J; Zhang, MM; Hu, JQ; Fan, YH; Reiter, RJ; Wang, HC; Sun, DD

Sun, DD (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian, Shaanxi, Peoples R China.; Sun, DD (reprint author), Fourth Mil Med Univ, Tangdu Hosp, Dept Cardiol, Xian, Peoples R China.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018; 22 (10): 5132

Abstract

Mitophagy eliminates dysfunctional mitochondria and thus plays a cardinal role in diabetic cardiomyopathy (DCM). We observed the favourable effects of......

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