High affinity CXCR4 inhibitors generated by linking low affinity peptides

Zhang, CZ; Huang, LNS; Zhu, RH; Meng, Q; Zhu, SY; Xu, Y; Zhang, HJ; Fang, X; Zhang, XQ; Zhou, J; Schooley, RT; Yang, XH; Huang, ZW; An, J

Huang, ZW; An, J (reprint author), Univ Calif San Diego, Sch Med, Dept Med, Div Infect Dis, La Jolla, CA 92037 USA.; Yang, XH (reprint author), Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Jilin, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019; 172 (): 174

Abstract

G-protein coupled receptors (GPCRs) are implicated in many diseases and attractive targets for drug discovery. Peptide fragments derived from protein ......

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