Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

Riemenschneider, H; Guo, Q; Bader, J; Frottin, F; Farny, D; Kleinberger, G; Haass, C; Mann, M; Hartl, FU; Baumeister, W; Hipp, MS; Meissner, F; Fernandez-Busnadiego, R; Edbauer, D

Edbauer, D (通讯作者),German Ctr Neurodegenerat Dis DZNE, Munich, Germany.;Fernandez-Busnadiego, R (通讯作者),Max Planck Inst Biochem, Dept Mol Struct Biol, Martinsried, Germany.;Edbauer, D (通讯作者),Munich Cluster Syst Neurol SyNergy, Munich, Germany.;Fernandez-Busnadiego, R (通讯作者),Univ Med Ctr Gottingen, Inst Neuropathol, Gottingen, Germany.;Fernandez-Busnadiego, R (通讯作者),Univ Gottingen, Cluster Excellence Multiscale Bioimaging Mol Mach, Gottingen, Germany.;Edbauer, D (通讯作者),Ludwig Maximilians Univ Munch

EMBO REPORTS, 2022; 23 (6):

Abstract

Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of amyotrophic lateral sclerosis and fronto-temporal dementia an......

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