m(6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity

Zhou, J; Zhang, XL; Hu, JJ; Qu, RH; Yu, ZB; Xu, H; Chen, HF; Yan, LC; Ding, CB; Zou, Q; Ye, YQ; Wang, ZT; Flavell, RA; Li, HB

Li, HB (corresponding author), Shanghai Jiao Tong Univ, Shanghai Inst Immunol, State Key Lab Oncogenes & Related Genes, Sch Med, Shanghai 200025, Peoples R China.; Li, HB (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Yale Inst Immune Metab, Shanghai 200025, Peoples R China.; Flavell, RA; Li, HB (corresponding author), Yale Univ, Dept Immunobiol, Sch Med, New Haven, CT 06520 USA.; Flavell, RA (corresponding author), Yale Univ, Howard Hughes Med Inst, Sch Med, New Haven, CT 06520 USA.

SCIENCE ADVANCES, 2021; 7 (25):

Abstract

N-6-methyladenosine (m(6)A) modification is dynamically regulated by "writer" and "eraser" enzymes. m(6)A "writers" have been shown to ensure the home......

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