Development of a Ruthenium Catalyzed Asymmetric Hydrogenation for fasiglzfam (TAK-875) Process: An Approach to the Trace Catalyst Loading

Yamada, M; Goto, M; Konishi, T; Yamashita, M; Kondo, Y; Yamano, M

Yamada, M (reprint author), Takeda Pharmaceut Co Ltd, Pharmaceut Sci, Proc Chem, Yodogawa Ku, 17-85 Jusohonmachi 2 Chome, Osaka 5328686, Japan.

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2017; 75 (5): 432

Abstract

A highly effective synthetic method via ruthenium catalyzed asymmetric hydrogenation was developed for (S)-methyl-2-(6-hydroxy-2,3-dihydrobenzofuran-3......

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