Mechanistic modeling of a human IgG(4) monoclonal antibody (tralokinumab) Fab-arm exchange with endogenous IgG(4) in healthy volunteers

Wang, B; Goodman, J; Roskos, LK

Wang, B (通讯作者)，Amador Biosci, 4695 Chabot Dr,Suite 200-265, Pleasanton, CA 94588 USA.;Roskos, LK (通讯作者)，AstraZeneca, BioPharmaceut, R&D, Clin Pharmacol & Safety Sci, 1 MedImmune Way, Gaithersburg, MD 20878 USA.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2022; 11 (4): 438

Abstract

Therapeutic IgG(4) antibodies engage in Fab-arm exchange with endogenous human immunoglobulin G4 (IgG(4)) to form monovalent hybrid molecules. A mecha......

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