A Closed-Tube Nested Quantitative PCR Assay for Rapid Detection of Intron 22 Inversions in the Factor VIII Gene

Jin, SN; Shang, QJ; Jin, WJ; Yang, LQ; Ye, Q; Wang, X; Zhang, TR; Hou, ML; Liu, YY; Han, JM; Ding, RX; Luan, J; Wang, XF; Jiang, MH; Ding, CM

Jin, SN; Ding, CM (corresponding author), Wenzhou Med Univ, Chashan Campus, Wenzhou 325035, Zhejiang, Peoples R China.

CLINICAL CHEMISTRY, 2020; 66 (2): 373

Abstract

BACKGROUND: An inversion of intron 22 in the Factor VIII gene (Inv22) is the causative mutation for 45% of severe hemophilia A cases. Available method......

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