Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid

Kang, S; Kim, W; Jeong, S; Lee, Y; Nam, J; Lee, S; Jung, Y

Jung, Y (reprint author), Pusan Natl Univ, Coll Pharm, Busan 609735, South Korea.

FREE RADICAL BIOLOGY AND MEDICINE, 2017; 108 ( ): 715

Abstract

Mesalazine (5-aminosalicylic acid, 5-ASA), a currently used drug for anti-inflammatory bowel disease, is easily oxidized by HOCl, a strong oxidant gen......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索