SARS-CoV-2 spike D614G change enhances replication and transmission

Zhou, B; Thao, TTN; Hoffmann, D; Taddeo, A; Ebert, N; Labroussaa, F; Pohlmann, A; King, J; Steiner, S; Kelly, JN; Portmann, J; Halwe, NJ; Ulrich, L; Trueb, BS; Fan, XY; Hoffmann, B; Wang, L; Thomann, L; Lin, XD; Stalder, H; Pozzi, B; de Brot, S; Jiang, NN; Cui, D; Hossain, J; Wilson, MM; Keller, MW; Stark, TJ; Barnes, JR; Dijkman, R; Jores, J; Benarafa, C; Wentworth, DE; Thiel, V; Beer, M

Wentworth, DE (corresponding author), Ctr Dis Control & Prevent, CDC COVID 19 Response, Atlanta, GA 30333 USA.; Benarafa, C; Thiel, V (corresponding author), Inst Virol & Immunol IVI, Mittelhausern, Switzerland.; Benarafa, C; Thiel, V (corresponding author), Univ Bern, Vetsuisse Fac, Dept Infect Dis & Pathobiol, Bern, Switzerland.; Beer, M (corresponding author), Friedrich Loeffler Inst, Inst Diagnost Virol, Greifswald, Germany.

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Abstract

During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike glycoprotein (S) has emerged; virus containing this substitution has b......

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