TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity

Sarathy, JP; Ragunathan, P; Cooper, CB; Upton, AM; Gruber, G; Dick, T

Gruber, G (corresponding author), Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore.; Dick, T (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore, Singapore.; Dick, T (corresponding author), Hackensack Meridian Hlth, Ctr Discovery & Innovat, Nutley, NJ 07110 USA.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020; 64 (2):

Abstract

The diarylquinoline F1FO-ATP synthase inhibitor bedaquiline (BDQ) displays protonophore activity. Thus, uncoupling electron transport from ATP synthes......

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