Targeted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance

Chan, PC; Wu, TN; Chen, YC; Lu, CH; Wabitsch, M; Tian, YF; Hsieh, PS

Hsieh, PS (reprint author), Natl Def Med Ctr, Dept Physiol & Biophys, Taipei, Taiwan.; Hsieh, PS (reprint author), NDMC, Inst Prevent Med, Taipei, Taiwan.; Hsieh, PS (reprint author), NDMC, Dept Med Res, Triserv Gen Hosp, Taipei, Taiwan.

CLINICAL SCIENCE, 2018; 132 (14): 1581

Abstract

Adipose tissue (AT) inflammation is crucial to the development of obesity-associated insulin resistance. Our aim was to investigate the contribution o......

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